Recent studies show that the combination of genetic factors and lifestyle choices, particularly sleep quality and exposure to daylight, significantly affects the development of brain decline.

最近的研究顯示，遺傳因素與生活方式的選擇，特別是睡眠品質與接觸日光的機會，會顯著影響大腦功能衰退的發展。

Research from Edith Cowan University, published in June 2026, examined how a specific gene called AQP4 helps the brain clear waste. The study, which included 351 healthy adults, found that people with certain versions of this gene experienced faster brain tissue loss if they did not get enough sleep. This suggests that daily habits can determine how genetic risks affect the brain. Consequently, doctors may one day use a person's biological profile to create personalized prevention plans, although researchers emphasized that there is not yet enough data to start routine genetic screening.

Edith Cowan 大學於 2026 年 6 月發表的研究，探討了名為 AQP4 的特定基因如何幫助大腦清除廢物。這項包含 351 位健康成年人的研究發現，若睡眠不足，擁有該基因特定版本的個體，其大腦組織流失速度較快。這顯示日常習慣可以決定遺傳風險如何影響大腦。因此，醫生未來或許能利用個人的生物特徵來制定個人化預防計畫，儘管研究人員強調目前尚無足夠數據來開始常規基因篩檢。

Furthermore, a large study of 90,000 adults published in General Psychiatry looked at the link between light exposure and dementia. The results indicate that spending time in bright daylight (over 1,000 lux) is associated with a 16 percent lower risk of dementia. Interestingly, this protective effect was much stronger for people with the APOE ε4 gene or those who naturally prefer staying up late, with risk reductions reaching 41 percent. Together, these studies highlight a shift toward combining genetic analysis with the study of biological rhythms to protect brain health.

此外，發表於《通用精神病學》(General Psychiatry) 的一項涉及 9 萬名成年人的大型研究，探討了光線接觸與失智症之間的聯繫。結果指出，在明亮日光下（超過 1,000 lux）活動與失智症風險降低 16% 相關。有趣的是，對於攜帶 APOE ε4 基因或天生傾向熬夜的人來說，這種保護效果更強，風險降低幅度可達 41%。綜合來看，這些研究凸顯了將遺傳分析與生物節奏研究相結合以保護大腦健康的趨勢。

Current evidence suggests that improving sleep quality and increasing exposure to daytime light may lower the risk of dementia, especially for people with high-risk genes.

目前的證據顯示，改善睡眠品質與增加接觸日光，可能會降低失智症風險，尤其是對於帶有高風險基因的人。