Many countries are looking at how to stop HIV. Africa wants to lead its own health work.

許多國家正在研究如何阻止 HIV。非洲希望主導自身的健康工作。

Many people lived longer since 2010. Fewer children died from HIV. But in 2025, some countries stopped giving money. This is bad. Hospitals lost doctors and medicine. Many children might get sick again.

自 2010 年起，許多人的壽命有所延長。死於 HIV 的兒童減少了。但在 2025 年，部分國家停止了撥款。這很糟糕。醫院失去了醫生與藥物。許多兒童可能會再次染病。

African leaders have a new plan. They do not want to ask other countries for money. They want to pay for their own health. They want to make 60 percent of their own medicine in Africa by 2040.

非洲領導人有一個新計劃。他們不想再向其他國家要求資金。他們希望自行支付醫療費用。他們的目標是在 2040 年前，在非洲生產 60% 的藥物。

There is a new medicine called Lenacapavir. People only need two shots a year. South Africa is using it now. But the medicine is expensive. Doctors say people must take it on time or it will not work.

目前有一款名為 Lenacapavir 的新藥。一年僅需注射兩劑。南非目前已在採用。但這種藥物價格昂貴。醫生表示必須準時用藥，否則將失去療效。

Africa wants to be independent. New medicines and local factories will help stop the virus.

非洲希望獨立。新藥與在地工廠將有助於阻止病毒。

The international community is currently reviewing how effective global HIV/AIDS programs are, as funding has become unstable and there is a new focus on allowing African nations to manage their own healthcare.

由於資金變得不穩定，且目前的重心轉向允許非洲國家管理自身的醫療保健，國際社會目前正在審視全球 HIV/AIDS 計畫的成效。

Data shows that HIV-related deaths and infections have dropped significantly since 2010. For example, deaths from pediatric AIDS fell by 69 percent, and twenty-two countries have stopped the transmission of the virus from mothers to children. However, sudden funding cuts in 2025 have caused serious problems for healthcare systems, leading to the end of medical contracts and a shortage of medicine. UNICEF and UNAIDS warn that if prevention and treatment services are reduced by 50 percent, millions of children in sub-Saharan Africa could face new infections or death by 2040.

數據顯示，自 2010 年起，HIV 相關的死亡人數與感染率大幅下降。例如，兒童愛滋病死亡率下降了 69%，且有 22 個國家已成功阻止病毒由母親傳給子女。然而，2025 年突然的資金削減對醫療體系造成了嚴重問題，導致醫療合約終止以及藥物短缺。UNICEF 與 UNAIDS 警告，如果預防與治療服務減少 50%，到 2040 年，撒哈拉以南非洲可能有數百萬名兒童將面臨新感染或死亡。

To address these issues, African countries have created the 'Common Africa Position' for the 2026 UN High-Level Meeting. This plan argues that the current system, which relies too much on foreign donors, is no longer effective. Instead, they are pushing for 'health sovereignty,' which means using their own national budgets to fund healthcare and integrating HIV care into general health services. Furthermore, they aim to produce 60 percent of their own health products by 2040 to ensure a steady supply of medicine and better pricing.

為了處理這些問題，非洲國家為 2026 年聯合國高級別會議制定了「非洲共同立場」。該計劃認為，目前過於依賴外國捐助者的系統已不再有效。相反，他們正推動「健康主權」，意即利用自身的國家預算資助醫療保健，並將 HIV 護理整合至一般醫療服務中。此外，他們的目標是在 2040 年前自行生產 60% 的醫療產品，以確保藥物供應穩定且價格更合理。

New technology is also changing how the disease is prevented. A new drug called Lenacapavir only requires two injections per year, which is a major improvement. While South Africa has started using this treatment, experts are concerned about the high cost and whether the supply will remain consistent. They emphasize that if patients stop receiving these powerful drugs, the virus could become resistant. Meanwhile, creating a vaccine remains difficult because the virus changes quickly, although a new trial in South Africa is being closely watched for success.

新技術也正在改變預防該疾病的方式。一種名為 Lenacapavir 的新藥一年僅需注射兩次，是一項重大進步。雖然南非已開始使用此治療，但專家擔心成本過高以及供應是否能維持穩定。他們強調，如果患者停止接受這些強力藥物，病毒可能會產生抗藥性。與此同時，由於病毒變異迅速，研發疫苗仍然困難，不過南非的一項新試驗正受到密切關注，期待能取得成功。

The global fight against HIV is at a turning point. The future of the epidemic will depend on whether African nations can become self-sufficient and whether new long-acting medicines can be distributed fairly.

全球對抗 HIV 正處於轉折點。疫情的未來將取決於非洲國家能否實現自給自足，以及新型長效藥物能否得到公平分配。

The international community is currently evaluating the efficacy of global HIV/AIDS interventions amidst significant funding volatility and a strategic shift toward African-led health autonomy.

面對資金大幅波動以及向非洲主導醫療自主的策略轉型，國際社會目前正在評估全球 HIV/AIDS 干預措施的成效。

Historical data indicate a substantial reduction in HIV-related mortality and transmission since 2010, characterized by a 69 percent decrease in pediatric AIDS deaths and the elimination of vertical transmission in twenty-two nations. However, the 2025 fiscal period witnessed abrupt funding contractions, which precipitated the degradation of healthcare infrastructure, including the termination of medical personnel contracts and the depletion of pharmaceutical inventories. UNICEF and UNAIDS projections suggest that a 50 percent reduction in prevention and treatment interventions could result in 1.8 million pediatric deaths and 3 million new pediatric infections by 2040, primarily within sub-Saharan Africa.

歷史數據顯示，自 2010 年起，HIV 相關死亡率與傳播率大幅下降，其中兒童愛滋病死亡人數減少了 69%，且有 22 個國家消除了母嬰傳播。然而，2025 財政年度出現了突然的資金縮減，導致醫療基礎設施惡化，包括終止醫療人員合約與藥品庫存耗盡。聯合國兒童基金會（UNICEF）與聯合國愛滋病專項計劃（UNAIDS）預測，若預防與治療干預措施減少 50%，到 2040 年可能會導致 180 萬名兒童死亡以及 300 萬宗新兒童感染個案，主要集中在撒哈拉以南非洲地區。

In response to these instabilities, African member states have articulated a 'Common Africa Position' for the 2026 UN High-Level Meeting. This framework advocates for a transition from a donor-dependent model to one of health sovereignty. The strategy emphasizes the integration of HIV care into primary healthcare systems and the escalation of domestic financing to ensure sustainability. A critical component of this rapprochement with autonomy is the objective to locally manufacture 60 percent of health products by 2040, utilizing the African Medicines Agency and the African pooled procurement mechanism to enhance bargaining power and supply chain security.

為應對這些不穩定情況，非洲會員國為 2026 年聯合國高級別會議提出了「非洲共同立場」。此框架主張由依賴捐助者的模式轉向醫療主權模式。該策略強調將 HIV 護理整合到基層醫療體系中，並增加國內資金投入以確保可持續性。實現自主化的一個關鍵環節是目標在 2040 年前將 60% 的醫療產品本地化生產，利用非洲藥品局與非洲集體採購機制來提升議價能力與供應鏈安全。

Technological advancements, specifically the introduction of Lenacapavir, represent a pivotal shift in prophylaxis. This long-acting antiretroviral drug, requiring only two injections annually, inhibits the assembly of HIV RNA molecules. While South Africa has commenced the rollout of this treatment, concerns persist regarding fiscal accessibility and supply consistency. Clinical experts warn that interruptions in the administration of such potent antiretrovirals could induce viral resistance. Concurrently, the development of a vaccine remains impeded by the high mutation rate of the virus, although the Brilliant 011 trial in South Africa is currently being monitored for potential breakthroughs.

技術進步，特別是 Lenacapavir 的引入，代表了預防措施的重大轉變。這種長效抗反轉錄病毒藥物每年僅需注射兩次，即可抑制 HIV RNA 分子的組裝。雖然南非已開始推行這種治療，但對於資金可負擔性與供應穩定性仍有憂慮。臨床專家警告，若此類強效抗反轉錄病毒藥物的用藥中斷，可能會導致病毒產生耐藥性。同時，由於病毒突變率高，疫苗開發仍然受阻，不過南非的 Brilliant 011 試驗目前正持續監測是否有突破性進展。

The global HIV response currently stands at a juncture where the transition toward African self-sufficiency and the adoption of long-acting pharmaceuticals will determine the trajectory of epidemic control.

全球 HIV 應對工作目前處於一個關鍵轉捩點，向非洲自給自足的轉型與長效藥物的採用，將決定疫情控制的走勢。